PhD Vanessa Valdiglesias García  

(PR-PX-XUA)

Department Psychology
Knowledgment area Behavioural Neuroscience
Research  Research group Diagnóstico conductual y molecular aplicado a la salud
Research lines - Toxicological assessment of nanomaterials - Study of biomarkers for frailty identification in elderly - Development of new biomarkers for human biomonitoring
Keywords Genetic toxicology. Nanotoxicology Immunotoxicology Psychophysiological effects of environmental and occupational exposures. Molecular markers Gene expression.
Contacto UDC directory
Orcid id0000-0002-5572-1089 ResearcherIDK-7728-2014 Scopus16551208900

Teaching

Subjects taught

This section shows the teaching given in degrees, masters and other officers studies in last 6 years.

Subject and involved studies Total hours
Congenital Disorders
Degree in Speech Therapy
40
Final Dissertation
Degree in Early Childhood Education
3
Final Dissertation
Degree in Speech Therapy
4
Genetic Toxicology
Master's in Molecular Cellular and Genetic Biology
7
Practicum II
Degree in Speech Therapy
8
Project
Master's in Molecular Cellular and Genetic Biology
8
Subject and involved studies Total hours
Cytogenetics
Primary Degree in Biology
20

EOG works and final master thesis directed

Directed or codirected by current teacher since 2013 year.

Analysis of micronuclei frequency in neuronal cells treated with titanium dioxide nanoparticle
Biomarkers and cognitive impairment in older adults
Adaptation period in the stage of Early Childhood Education: analysis of a planning example.
Analysis of internalization and chromosome alterations in lung cells treated with titanium dioxide nanoparticles
Proposal for an intervention program in a case of Williams´Syndrome.
Repair capacity in glial cells exposed to iron oxide nanoparticles
Assessment of iron oxide nanoparticle cytotoxicity on human neuronal cells by flow cytometry.
ASSESSMENT OF GENETIC DAMAGE AND CELL DEATH IN MUSSEL CELLS EXPOSED TO OKADAIC ACID
GENOTOXICITY ASSESSMENT RELATED EXPOSURE TO METAL OXIDE NANOPARTICLES IN NEURAL CELLS

Research results

Select merit type and year to query research merits.

Toxicological assessment of silica-coated iron oxide nanoparticles in human astrocytes

Authors Fernández-Bertólez, N., Costa, C., Brandao, F., Kiliç, G., Duarte, J.A., Teixeira, J.P., Pásaro, E., Valdiglesias, V., Laffon, B.
Journal FOOD AND CHEMICAL TOXICOLOGY Vol. 118 (pages 13 to 23)
DOI https://doi.org/10.1016/j.fct.2018.04.058

Frailty in older adults is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations

Authors Marcos-Pérez, D., Sánchez-Flores, M., Maseda, A., Lorenzo-López, L., Millán-Calenti, J.C., Gostner, J.M., Fuchs, D., Pásaro, E., Laffon, B., Valdiglesias, V.
Journal Frontiers in Immunology Vol. 9 (pages 1056 to 1056)
DOI https://doi.org/10.3389/fimmu.2018.01056

Are iron oxide nanoparticles safe? Current knowledge and future perspectives

Authors Valdiglesias, V., Natalia Fernández-Bertólez, Kiliç, G., Costa, C., Costa, S., Sonia Fraga, Bessa, M.J., Eduardo José Pasaro Méndez, Teixeira, J.P., Laffon, B.
Journal JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (pages 53 to 63)
DOI https://doi.org/10.1016/j.jtemb.2016.03.017

Early Genotoxic and Cytotoxic Effects of the Toxic Dinoflagellate Prorocentrum lima in the Mussel Mytilus galloprovincialis

Authors Prego-Faraldo, M.V., Valdiglesias, V., Laffon, B., Méndez, J., Eirín-López, J.M.
Journal Toxins (pages 159 to 173)
DOI https://doi.org/10.3390/toxins8060159

In Vitro Analysis of Early Genotoxic and Cytotoxic Efffects of Okadaic Acid in Different Cell Types of the Mussel Mytilus galloprovincialis

Authors Prego-Faraldo, M.V., Valdiglesias, V., Laffon, B., Eirín-López, J.M., Méndez, J.
Journal JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES Vol. 78 (pages 814 to 824)
DOI https://doi.org/10.1080/15287394.2015.1051173

Silica-coated iron oxide nanoparticles do not induce DNA double strand breaks or aneugenicity sin SHSY5Y neuronal cells

Authors Sánchez-Flores, M., G. Kiliç, C. Costa, N. Fernández-Vertólez, S. Costa, J. P. Teixeira, Eduardo José Pasaro Méndez, Valdiglesias, V., Laffon, B.
Journal TOXICOLOGY LETTERS

Oxidative stress induced by silica-coated iron oxide nanoparticles in SHSY5Y neuronal cells

Authors G. Kiliç, C. Costa, Fernández-Bertólez, N., S. Costa, J. Teixeira, Eduardo José Pasaro Méndez, Laffon, B., M. Vdz Park, Valdiglesias, V.
Journal TOXICOLOGY LETTERS

In vitro toxicity screening of silica-coated superparamagnetic iron oxide nanoparticles in glial cells

Authors C. Costa, Brandâo, F., Bessa, M.J., S. Costa, Valdiglesias, V., G. Kiliç, Fernández-Bertólez, N., Eduardo José Pasaro Méndez, Laffon, B., J. Teixeira
Journal TOXICOLOGY LETTERS

Okadaic acid meet and greet: an insight into detection methods, response strategies and genotoxic effects in marine invertebrates

Authors M. Verónica Prego-Faraldo, Valdiglesias, V., Méndez, J., Eirín-López, J.M.
Journal MARINE DRUGS Vol. 11 (pages 2829 to 2835)
DOI https://doi.org/10.3390/md110x000x

Okadaic Acid: More than a Diarrheic Toxin

Authors Valdiglesias, V., Prego-Faraldo, M.V., Pásaro, E., Méndez, J., Laffon, B.
Journal MARINE DRUGS Vol. 11 (pages 4328 to 4349)
DOI https://doi.org/10.3390/md11114328

The marine toxin okadaic acid induces alterations in the expression level of cancer-related genes in human neuronal cells

Authors Valdiglesias, V., Fernández-Tajes, J., Méndez, J., Pásaro, E., Laffon, B.
Journal ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Vol. 92 (pages 303 to 311)
DOI https://doi.org/10.1016/j.ecoenv.2013.03.009

Endocrine and immunological parameters in individuals involved in Prestige spill cleanup tasks seven years after the exposure

Authors Laffon, B., Francisco Aguilera, Julia Ríos-Vázquez, Julia García-Lestón, Fuchs, D., Valdiglesias, V., Pásaro, E.
Journal ENVIRONMENT INTERNATIONAL Vol. 59 (pages 103 to 111)

An ECVAG inter-laboratory validation study of the comet assay:inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells

Authors Clara Ersson, Peter Moller, Lykke Forchhammer, Steffen Loft, Amaya Azqueta, Roger W.L. Godschalk, Frederik J. van Schooten, George D.D. Jones, Jennifer A. Higgins, Marcus Cooke, Vilas Mistry, Mahsa Karbaschi, David H. Phillips, Osman Sozeri, Michael N. Routledge, Kirsty Nelson-Smith, Patrizia Riso, Marisa Porrini, Giuseppe Matullo, Alessandra Allione, Maciej Stepnik, Magdalena Ferlinska, Joâo P. Teixeira, Costa, S., Laura-Ana Corcuera, Adela López de Cerain, Laffon, B., Valdiglesias, V., Andrew R. Collins, Lennart Moller
Journal MUTAGENESIS Vol. 28 Num. 3 (pages 279 to 286)
DOI https://doi.org/10.1093/mutage/get001

Comparative study on effects of two different types of titanium dioxide nanoparticles on human neuronal cells

Authors Valdiglesias, V., Costa, C., Vyom SHARMA, Kiliç, G., Eduardo José Pasaro Méndez, Teixeira, J.P., Alok Dhawan, Laffon, B.
Journal FOOD AND CHEMICAL TOXICOLOGY Vol. 57 (pages 352 to 361)

Neuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticles

Authors Valdiglesias, V., Costa, C., Kiliç, G., Costa, S., Eduardo José Pasaro Méndez, Laffon, B., Teixeira, J.P.
Journal ENVIRONMENT INTERNATIONAL Vol. 55 (pages 92 to 100)

Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization

Authors Valdiglesias, V., Juan Fernández Tajes, Pásaro, E., Méndez, J., Laffon, B.
Journal BMC GENOMICS Vol. 13 (pages 46 to 59)
DOI https://doi.org/10.1186/1471-2164-13-46

In vivo genotoxicity assessment in rats exposed to Prestige-like oil by inhalation

Authors Valdiglesias, V., Kiliç, G., Costa, C., Amor-Carro, O., Mariñas-Pardo, L., Ramos-Barbón, D., Méndez, J., Pásaro, E., Laffon, B.
Journal JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES Vol. 75 (pages 756 to 764)
DOI https://doi.org/10.1080/15287394.2012.689801

Alterations in metabolism-related genes induced in shsy5y cells by okadaic acid exposure

Authors Valdiglesias, V., Fernández-Tajes, J., Costa, C., Méndez, J., Pásaro, E., Laffon, B.
Journal JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES Vol. 75 (pages 844 to 856)
DOI https://doi.org/10.1080/15287394.2012.690703

Inter-laboratory variation in DNA damage using a standard comet assay protocol

Authors Lykke Forchhammer, Clara Ersson, Steffen Loft, Lennart Moller, Roger W.L. Godschalk, Frederik J. van Schooten, George D.D. Jones, Jennifer A. Higgins, Marcus Cooke, Vilas Mistry, Mahsa Karbaschi, Andrew R. Collins, Amaya Azqueta, David H. Phillips, Osman Sozeri, Michael N. Routledge, Kirsty Nelson-Smith, Patrizia Riso, Marisa Porrini, Giuseppe Matullo, Alessandra Allione, Maciej Stepnik, Magdalena Komorowska, Teixeira, J.P., Costa, S., Laura-Ana Corcuera, Adela López de Cerain, Laffon, B., Valdiglesias, V., Peter Moller
Journal MUTAGENESIS Vol. 27 Num. 6 (pages 665 to 672)
DOI https://doi.org/10.1093/mutage/ges032

Okadaic acid induces morphological changes, apoptosis and cell cycle alterations in different human cell types

Authors Valdiglesias, V., Laffon, B., Pásaro, E., Méndez, J.
Journal JOURNAL OF ENVIRONMENTAL MONITORING Vol. 13 Num. 6 (pages 1831 to 1840)
DOI https://doi.org/10.1039/c0em00771d

Induction of oxidative DNA damage by the marine toxin okadaic acid depends on human cell type

Authors Valdiglesias, V., Laffon, B., Pásaro, E., Eduardo Cemeli, Diana Anderson, Méndez, J.
Journal TOXICON Vol. 57 Num. 6 (pages 882 to 888)
DOI https://doi.org/10.1016/j.toxicon.2011.03.005

Evaluation of okadaic acid-induced genotoxicity in human cells using the micronucleus test and gamma H2AX analysis

Authors Valdiglesias, V., Laffon, B., Pásaro, E., Méndez, J.
Journal JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES Vol. 74 (pages 980 to 992)
DOI https://doi.org/10.1080/15287394.2011.582026

Assays to determine DNA repair ability

Authors Valdiglesias, V., Pásaro, E., Méndez, J., Laffon, B.
Journal JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES Vol. 74 (pages 1094 to 1109)
DOI https://doi.org/10.1080/15287394.2011.582320

Cellular and Molecular Toxicity of Iron Oxide Nanoparticles.

Authors Laffon, B.. Fernández-Bertólez, N.. Costa, C.. Brandâo, F.. Teixeira, J.P.. Pasaro,E.. Valdiglesias, V.
Book Cellular and Molecular Toxicology of Nanoparticles
Vol. 1048 Publishing: Springer.
ISBN: 978-3-319-72040-1
Pages From 199 to 213

Lead Exposure: Assesssment of Effects on the Genetic Material

Authors María Sánchez-Flores. Laffon, B.. Julia García-Lestón. Méndez, J.. Pásaro, E.. Valdiglesias, V.
Book Lead Exposure and Poisoning
Publishing: Nova Biomedical Books.
ISBN: 978-1-63482-699-0
Pages From 1 to 40

Okadaic acid

Authors Valdiglesias, V.. Laffon, B.. Juan Fernández Tajes. Méndez, J.
Book Encyclopedia of Toxicology (Third Edition)
Vol. 3 Publishing: Elsevier.
ISBN: 9780123864543
Pages From 682 to 686

Toxicología Genética: fundamentos y metodologías

Authors Laffon, B.. Valdiglesias, V.
Book Investigación aplicada en medicina respiratoria. Un ABC para entender las innovaciones biomédicas
Publishing: Editorial Andavira.
ISBN: 978-84-8408-724-3
Pages From 117 to 133

Frailty in the elderly: analysis of the relationship with genomic alterations and cell repair

Autor María Sánchez Flores
Director/s Blanca Laffon Lage; Vanessa Valdiglesias García
Scope Facultad de Ciencias
Qualification Sobresaliente Cum Laude

Cellular and molecular effects of metal oxide nanoparticles on human neuronal cells

Autor Gözde Kiliç
Director/s Blanca Laffon Lage; Vanessa Valdiglesias García
Scope Biología Celular y Molecular
Qualification Sobresaliente Cum Laude

Genotoxocity assessment of iron oxide nanoparticles on human astrocytes
Society of Toxicology 57th annual meeting
International

Authors Fernández-Bertólez, N., Costa, C., Brandao, F., Fraga, S., Pásaro, E., Laffon, B., Valdiglesias, V., Teixeira, J.P.
Place San Antonio (Texas) (Estados Unidos)

Genotoxic Effects Related to Participation in Prestige Oil Clean-up: Immediate and Follow-up
Gulf of Mexico oil spill and ecosystem science conference 2016. Organizadora de la sesión One health: unraveling the interconnectedness between human and ecosystem health through the lens of oil spills.
International

Authors B. Laffon, V. Valdiglesias, J. Méndez, E. Pásaro
Organization Gulf of Mexico Research Initiative
Place Tampa (Estados Unidos)

Considering cell type for in vitro neurogenotoxicity testing: Neuronal vs. glial cell sensitivity
Ibero-American Meeting on Toxicology and Environmental Health (IBAMTOX 2016)
International

Authors Laffon, B., Fernández-Bertólez, N., J. Méndez, E. Pásaro, V. Valdiglesias
Place Porto (Portugal)

Increased neopterin production and tryptophan breakdown in the frail elderly, potential pathophysiologic consequences
34th International Winter Workshop. Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics
International

Authors Gostner, J., Marcos-Pérez, D., Millán-Calenti, J.C., Sánchez-Flores, M., Maseda, A., Valdiglesias, V., Lorenzo-López, L., Strasser, B., Pásaro, E., Fuchs, D., Laffon, B.
Place Innsbruck (Austria)
DOI https://doi.org/10.1515/pterid-2015-0007

Neopterin concentrations and tryptophan breakdown rates in the elderly are influenced by life style and dietary habits
34th International Winter Workshop. Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics
International

Authors Fuchs, D., Gostner, J., Sánchez-Flores, M., Millán-Calenti, J.C., Marcos-Pérez, D., Maseda, A., Pásaro, E., Strasser, B., Lorenzo-López, L., Laffon, B., Valdiglesias, V.
Place Innsbruck (Austria)
DOI https://doi.org/10.1515/pterid-2015-0007

Uso del ensayo del cometa para evaluar el daño oxidativo inducido por ácido ocadaico en hemocitos de mejillón
XV Congreso Nacional y I Congreso Ibérico de Acuicultura
National

Authors M. V. Prego-Faraldo, V. Valdiglesias, J. Fernández-Pérez, J. M. Eirín López, J. Méndez
Place Huelva (España)

Flow cytometry assessment of cell death in haemocytes from Mytilus galloprovincialis exposed to okadaic acid
3rd International Congress on Environmental Health (ICEH2014)
International

Authors Prego-Faraldo, M.V., Valdiglesias, V., Laffon, B., Eirín-López, J.M., Méndez, J.
Place O Porto (Portugal)

Evaluation of in vitro cytotoxic effects of oleic acid-coated magnetite nanoparticles on human neuronal cells
3rd International Congress on Environmental Health (ICEH2014)
International

Authors M. Verónica Prego-Faraldo, Costa, C., Costa, S., Kiliç, G., Aida Castelo, Teixeira, J.P., Méndez, J., Valdiglesias, V., Laffon, B., Pásaro, E.
Place O Porto (Portugal)

Assessment of okadaic acid genotoxicity on cells of the mussel Mytilus galloprovincialis.
ICES Annual Science Conference
International

Authors Prego-Faraldo, M.V., Valdeiglesias, V., Hidalgo, C., Laffon, B., Eirín-López, J.M., Méndez, J.
Organization ICES
Place Coruña, A (España)

Cytotoxicity of iron oxide nanoparticles with different coatings on human neuronal cells
50th Congress of the European Societies of Toxicology (EUROTOX 2014)
International

Authors Costa, C., Kiliç, G., Brandâo, F., Bessa, M.J., Costa, S., Pásaro, E., Valdiglesias, V., Laffon, B., Teixeira, J.P.
Place Edimburgo (Reino Unido)
DOI https://doi.org/10.1016/j.toxlet.2014.06.673

Neurotoxicity assessment of zinc oxide nanoparticles: cytotoxic and genotoxic effects
49th Congress of the European Societies of Toxicology (EUROTOX 2013)
International

Authors Kiliç, G., Costa, C., Teixeira, J.P., Pásaro, E., Valdiglesias, V., Laffon, B.
Place Interlaken (Suiza)
DOI https://doi.org/10.1016/j.toxlet.2013.05.600

In-vivo evaluation of genotoxic effects in rats exposed to Prestige-like oil by inhalation
Nanosafety Congress Turkey 2012
International

Authors Kiliç, G., Amor-Carro, O., Mariñas-Pardo, L., Ramos-Barbón, D., Méndez, J., Pásaro, E., Laffon, B., Valdiglesias, V.
Organization Tübitak (Turkish National Research Council)
Place Antalya (Turquía)

Genotoxic effects of inhalatory oil exposure in Brown Norway and Wistar rats
European Environmental Mutagen Society (EEMS)
International

Authors V. Valdiglesias, J. García-Lestón, G. Kiliç, O. Amor-Carro, D. Ramos-Barbón, J Méndez, E. Pásaro, B. Laffon
Place Barcelona (España)

Evaluation of genotoxic and immunotoxic effects in people occupationally exposed to lead
International Conference on Occupational and Environmental Health (ICOEH 2011)
International

Authors Julia García-Lestón, J. Roma-Torres, C. Costa, P. Coelho, S. Costa, S. Monteiro, O. Mayan, V. Valdiglesias, J. P. Teixeira, J. Méndez, E. Pásaro, B. Laffon
Organization National Institute of Health - Portugal
Place Oporto (Portugal)

Okadaic acid: just a diarrheic toxin?
International Conference on Occupational and Environmental Health (ICOEH 2011)
International

Authors Valdiglesias, V., J. García-Lestón, J. Méndez, E. Pásaro, E. Cemeli, D. Anderson, B. Laffon
Organization National Institute of Health - Portugal
Place Oporto (Portugal)

Leukocytes genotoxic damage in rats exposed to prestige-like oil by inhalation
International Conference on Occupational and Environmental Health (ICOEH 2011)
International

Authors Kiliç, G., Valdiglesias, V., Julia García-Lestón, Amor-Carro, O., Mariñas-Pardo, L., Ramos-Barbón, D., Méndez, J., Pásaro, E., Laffon, B.
Organization National Institute of Health - Portugal
Place Oporto (Portugal)

Comet assay to determine DNA damage and repair ability in rats exposed to Prestige-like oil
9th International Comet Assay Workshop
International

Authors Kiliç, G., Valdiglesias, V., Julia García-Lestón, Amor-Carro, O., Mariñas-Pardo, L., Ramos-Barbón, D., Méndez, J., Pásaro, E., Laffon, B.
Place Kusadasi (Turquía)

Cell cycle alterations and apoptosis assessment in SHSY5Y human neuroblastoma cells exposed t okadaic acid
XII International Congress of Toxicology
International

Authors V. Valdiglesias, J. García-Lestón, E. Pásaro, J Méndez, B. Laffon
Place Barcelona (España)
DOI https://doi.org/10.1016/j.toxlet.2010.03.1090

Cytotoxic and genotoxic effects of okadaic acid in human neuroblastoma cells
40th Annual Meeting of European Environmental Mutagen Society
International

Authors Valdiglesias, Vanessa, Méndez, Josefina, Pásaro, E., Cemeli, Eduardo, Anderson, Diana, García-Lestón, Julia, Laffon, Blanca
Place Oslo (Noruega)

Evaluación de la genotoxicidad en células humanas expuestas a ácido ocadaico
XIX Congreso de la Sociedad Española de Mutagénesis Ambiental
National

Authors Valdiglesias, Vanessa, Laffon, Blanca, Pásaro, E., Méndez, Josefina
Organization Sociedad Española de Mutagénesis Ambiental
Place Coruña, A (España)

Assessment of apoptosis and cell cycle alterations in human peripheral blood lymphocytes exposed to okadaic acid
46th Congress of the European Societies of Toxicology
International

Authors Valdiglesias, V., Laffon, B., Julia García-Lestón, Pásaro, E., Méndez, J.
Place Dresden (Alemania)
DOI https://doi.org/10.1016/j.toxlet.2009.06.202

effects of occupational exposure to lead: flow cytometric study
46th Congress of the European Societies of Toxicology
International

Authors Laffon, B., Julia García-Lestón, Roma-Torres, J., Teixeira, J.P., Costa, C., Coelho, P., Silvia Monteiro, Mayan, O., Valdiglesias, V., Pásaro, E., Méndez, J.
Place Dresden (Alemania)
DOI https://doi.org/10.1016/j.toxlet.2009.06.513