| Research | Research group Nanochemistry and Self-Assembly for Biological Sciences |
| Research lines | Biomimetic construction of functional artificial cells, Chemoselective depalmitoylation of proteins in living cells: targeting protein lipidation in disease |
| Keywords | Membrane Chemistry, Chemical Biology, Supramolecular Chemistry, Synthetic Biology, Lipid, Peptide, Biomimetic, Self-assembly, Artificial Cell |
| Contacto | UDC directory |
| Orcid id0000-0002-0321-0156 ResearcherIDN-3440-2017 Scopus8863926900 | |
This section shows the teaching given in degrees, masters and other officers studies in last 6 years.
| Subject and involved studies | Type | Distance hours | Total hours |
|---|---|---|---|
| Chemistry Laboratory 1 | Core | 0 | 60 |
| Molecular Machines | Optional | 0 | 10 |
| Supramolecular Chemistry | Compulsory | 0 | 10 |
| Supramolecular Chemistry | Optional | 0 | 14 |
| Subject and involved studies | Type | Distance hours | Total hours |
|---|---|---|---|
|
Chemistry Laboratory 1
Degree in Chemistry by the University of A Coruña
|
Core | 0 | 60 |
|
Molecular Machines
Degree in Nanoscience and Nanotechnology
|
Optional | 0 | 4 |
|
Supramolecular Chemistry
Degree in Nanoscience and Nanotechnology
|
Compulsory | 0 | 16 |
| Subject and involved studies | Type | Distance hours | Total hours |
|---|---|---|---|
|
Chemistry Laboratory 1
Degree in Chemistry by the University of A Coruña
|
Core | 0 | 60 |
|
Supramolecular Chemistry
Degree in Nanoscience and Nanotechnology
|
Compulsory | 0 | 6 |
|
Supramolecular Chemistry
Master in Chemistry Research and Industrial Chemistry
|
Optional | 0 | 14 |
| Subject and involved studies | Type | Distance hours | Total hours |
|---|---|---|---|
|
Chemistry of Natural Products
Master in Chemistry Research and Industrial Chemistry
|
Optional | 0 | 4.5 |
|
Medicinal Chemistry
Degree in Chemistry by the University of A Coruña
|
Optional | 0 | 15.75 |
|
Medicinal Chemistry
Master in Chemistry Research and Industrial Chemistry
|
Optional | 0 | 4 |
Defined tutoring by teacher for 2024/2025 academic course.
| Quarter | Day | Site |
|---|---|---|
| 1st quarter |
Monday
10:00 a 12:00 |
Contactar por Email |
| 2nd quarter |
Monday
10:00 a 12:00 |
Contactar por Email |
| 2nd chance |
Monday
10:00 a 12:00 |
Contactar por Email |
Directed or codirected by current teacher since 2013 year.
| Dissipative artificial cells modulated by chemical fuels |
| Fabrication of artificial cells by self-assembly of single-chain Beta-D-glycopyranose-based amphiphiles |
| Lipopeptide nanocarriers for targeted cellular uptake |
| Nanomaterials for virus mimicry: new tools for Biomedicine |
| Protein lipidation in disease: development of novel therapeutic agents |
| Chemoselective construction of functional artificial cells |
| Fabrication of functional artificial cells. |
| Synthetic organelles for programmable spatial organization of biomolecules |
| Targeting protein lipidation in disease: synthesis of chemoselective depalmitoylating agents |
Select merit type and year to query research merits.
Células artificiales lipopeptídicas: construcción in situ de compartimentos sintéticos altamente funcionales (CELL). (Proxecto Excelencia 2024)
| Funding entity | Consellería de Educación, Ciencia, Universidades e Formación Profesional |
| Main researches | Roberto Javier Brea Fernández |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/01/2024 to 20/11/2026 |
AYUDAS PARA LA CONSOLIDACIÓN Y ESTRUTURACIÓN DE UNIDADES DE INVESTIGACIÓN COMPETITIVAS. GPC 2023
| Funding entity | Consellería de Cultura, Educación e Ordenación Universitaria |
| Main researches | Francisco Fernández Trillo |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/01/2023 to 20/11/2025 |
Orgánulos sintéticos para la organización espacial programable de biomoléculas (SynOrg)
| Funding entity | Ministerio de Ciencia e Innovación |
| Main researches | Roberto J. Brea |
| Type | Proyecto Programas Nacionales |
| Dates | From 01/09/2022 to 31/08/2025 |
Delipidación quimioselectiva de proteínas en células vivas: apuntando a la lipidación de proteínas en enfermedades
| Funding entity | JUNTA DE ANDALUCÍA |
| Main researches | Roberto J. Brea |
| Type | Proyecto Programas Autonomicos |
| Dates | From 29/04/2021 to 28/04/2025 |
Delipidación quimioselectiva de proteínas en células vivas: apuntando a la lipidación de proteínas en enfermedades
| Funding entity | Xunta de Galicia |
| Main researches | Roberto J. Brea |
| Type | Proyecto Programas Autonomicos |
| Dates | From 24/07/2021 to 23/07/2025 |
Chemoenzymatic construction of a programmable synthetic endoplasmic reticulum
| Funding entity | National Science Foundation (NSF) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/08/2021 to 31/07/2026 |
Collaborative research: booting up a mirror cell
| Funding entity | National Science Foundation (NSF) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/09/2019 to 31/08/2023 |
RoL:EAGER:DESYN-C3 - Programmable porous lipid sponges as synthetic cell factories
| Funding entity | National Science Foundation (NSF) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/09/2018 to 31/08/2020 |
Fully synthetic self-regulated cytoskeleton
| Funding entity | Human Frontier Science Program (HFSP) |
| Main researches | Javier Montenegro, Neal K. Devaraj |
| Type | Proyecto Internacional |
| Dates | From 01/11/2017 to 31/10/2020 |
Site-specific covalent tagging of RNA for live cell imaging and affinity purification
| Funding entity | The Camille and Henry Dreyfus Foundation |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/07/2016 to 30/06/2021 |
Amplifying PET imaging signals for in vivo detection of pancreatic beta-cells
| Funding entity | National Institutes of Health (NIH) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 25/09/2016 to 30/06/2021 |
Observing and controlling dynamics in artificial cells
| Funding entity | Department of Defense (DURIP) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/09/2015 to 30/08/2016 |
Controlling functional group architecture in artificial cells
| Funding entity | Department of Defense (Army Corps of Engineers) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/03/2014 to 28/02/2017 |
Artificial life forms: confined biochemical processes in self-assembled non-natural cellular systems
| Funding entity | Human Frontier Science Program (HFSP) |
| Main researches | Roberto J. Brea |
| Type | Proyecto Internacional |
| Dates | From 01/04/2014 to 31/03/2017 |
Dynamic artificial cells composed of synthetic bioorthogonal membranes
| Funding entity | Department of Defense (Army Research Office) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/09/2013 to 31/08/2018 |
Vesicle growth driven by catalytic lipid synthesis
| Funding entity | National Science Foundation (NSF) |
| Main researches | Neal K. Devaraj |
| Type | Proyecto Otros Programas |
| Dates | From 01/09/2013 to 31/08/2018 |
Consolidación e estructuración de unidades de investigación competitivas - REDES
| Funding entity | Xunta de Galicia |
| Main researches | Enrique Guitián Rivera |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/06/2012 to 01/06/2014 |
Nanotubos peptídicos: síntesis y aplicaciones. Hacia una síntesis práctica de taxanos
| Funding entity | MINISTERIO DE EDUCACIÓN Y CIENCIA |
| Main researches | Juan R. Granja Guillán |
| Type | Proyecto Programas Nacionales |
| Dates | From 01/01/2011 to 31/12/2013 |
Consolidación e estructuración de unidades de investigación competitivas - GRUPOS
| Funding entity | Xunta de Galicia |
| Main researches | José Luis Mascareñas Cid |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/01/2010 to 31/12/2012 |
Magnetic nanocontainers for combined hyperthermia and controlled drug release (MAGNIFYCO)
| Funding entity | Unión Europea |
| Main researches | Juan R. Granja Guillán |
| Type | Contrato |
| Dates | From 01/01/2010 to 30/06/2010 |
Consolidación e estructuración de unidades de investigación (redes de investigación)
| Funding entity | Xunta de Galicia |
| Main researches | Enrique Guitián Rivera |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/01/2009 to 31/12/2010 |
Herramientas y estrategias moleculares para el estudio y modificación de procesos biológicos de relevancia biomédica
| Funding entity | MINISTERIO DE EDUCACIÓN Y CIENCIA |
| Main researches | José Luis Mascareñas Cid |
| Type | Proyecto Programas Nacionales |
| Dates | From 01/01/2007 to 31/12/2010 |
Tácticas supramoleculares para o desenvolvemento de biomoléculas funcionales
| Funding entity | Xunta de Galicia |
| Main researches | José Luis Mascareñas Cid |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/10/2006 to 01/10/2009 |
Grupos de referencia competitiva
| Funding entity | Xunta de Galicia |
| Main researches | José Luis Mascareñas Cid |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/12/2006 to 31/10/2009 |
Novos herbicidas ecolóxicos e selectivos: deseño, síntese e avaliación biolóxica
| Funding entity | Xunta de Galicia |
| Main researches | José L. Castedo Expósito |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/08/2005 to 01/08/2008 |
Diseño y síntesis de moléculas biofuncionales no naturales. Desarrollo de agentes anticáncer y antimicrobianos
| Funding entity | MINISTERIO DE EDUCACIÓN Y CIENCIA |
| Main researches | José Luis Mascareñas Cid |
| Type | Proyecto Programas Nacionales |
| Dates | From 01/12/2004 to 01/12/2007 |
Biomedical research in organic chemistry
| Funding entity | The Scripps Research Institute |
| Main researches | M. Reza Ghadiri |
| Type | Contrato |
| Dates | From 06/04/2003 to 04/08/2003 |
Deseño, síntese e caracterización de derivados peptídicos como posibles axentes anticanceríxenos e antimicrobianos
| Funding entity | Xunta de Galicia |
| Main researches | Juan R. Granja Guillán |
| Type | Proyecto Programas Autonomicos |
| Dates | From 01/10/2002 to 01/10/2005 |
HRas selective depalmitoylating compositions and the use thereof
| Type | Patente |
| Entity | University of California San Diego |
| Authors | Devaraj, Neal K., Rudd, Andrew K., Brea, Roberto J. |
| Application date | 15/08/2019 |
Self-assembling lipopeptide nanocarriers for targeted cellular uptake
| Type | Patente |
| Entity | University of California San Diego |
| Authors | Devaraj, Neal K., Cho, Christy J., Brea, Roberto J. |
| Application date | 06/09/2019 |
Amphiphilic thiol compounds and uses thereof
| Type | Patente |
| Entity | University of California San Diego |
| Authors | Brea, Roberto J., Rudd, Andrew K., Devaraj, Neal K. |
| Application date | 12/03/2019 |
| Approval date | 19/09/2019 |
Lipids for treatment of neuronal ceroid lipofuscinoses
| Type | Patente |
| Entity | University of California San Diego |
| Authors | Brea, Roberto J., Rudd, Andrew K., Devaraj, Neal K. |
| Application date | 12/03/2018 |
Prodrug strategy for in vivo depalmitoylation of proteins
| Type | Patente |
| Entity | University of California San Diego |
| Authors | Rudd, Andrew K., Brea, Roberto J., Devaraj, Neal K. |
| Application date | 02/10/2018 |
In situ lipid synthesis for protein reconstitution
| Type | Patente |
| Entity | University of California San Diego |
| Authors | Brea, Roberto J., Cole, Christian M., Lyda, Brent, Sunahara, Roger K., Devaraj, Neal K. |
| Application date | 02/03/2017 |
| Approval date | 07/09/2018 |
Ciclopéptidos marcados magnéticamente con complejos de lantánidos
| Type | Patente |
| Entity | Universidade de Santiago de Compostela (USC) |
| Authors | Brea, Roberto J., Ballesteros, Paloma, Granja, Juan R., Pérez, Elena, Castedo, Luis, Soler, Jordi, Reiriz, César |
| Application date | 24/06/2008 |
| Approval date | 29/09/2011 |
Controlling Protein Enrichment in Lipid Sponge Phase Droplets using SNAP-Tag Bioconjugation
| Authors | Moinpour, Mahta, Fracassi, Alessandro, Roberto J. Brea, Salvador-Castell, Marta, Pandey, Sudip, Edwards, Madison M., Seifert, Soenke, Joseph, Simpson, Sinha, Sunil K., Devaraj, Neal K. |
| Journal | CHEMBIOCHEM Vol. 23 Num. 5 |
| DOI | https://doi.org/10.1002/cbic.202100624 |
Rapid and Sequential Dual Oxime Ligation Enables De Novo Formation of Functional Synthetic Membranes from Water-Soluble Precursors
| Authors | Flores, Judith, Roberto J. Brea, Lamas, Alejandro, Fracassi, Alessandro, Salvador-Castell, Marta, Xu, Cong, Baiz, Carlos R., Sinha, Sunil K., Devaraj, Neal K. |
| Journal | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 61 Num. 29 |
| DOI | https://doi.org/10.1002/anie.202200549 |
In situ synthesis of artificial lipids
| Authors | Lomba-Riego, Lucía, Calvino-Sanles, Esther, Brea, Roberto J. |
| Journal | CURRENT OPINION IN CHEMICAL BIOLOGY |
Expression of Fatty Acyl-CoA Ligase Drives One-Pot De Novo Synthesis of Membrane-Bound Vesicles in a Cell-Free Transcription-Translation System
| Authors | Bhattacharya, Ahanjit, Cho, Christy J., Roberto J. Brea, Devaraj, Neal K. |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 143 Num. 29 (pages 11235 to 11242) |
| DOI | https://doi.org/10.1021/jacs.1c05394 |
Chemoenzymatic Generation of Phospholipid Membranes Mediated by Type I Fatty Acid Synthase
| Authors | Khanal, Satyam, Roberto J. Brea, Burkart, Michael D., Devaraj, Neal K. |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 143 Num. 23 (pages 8533 to 8537) |
| DOI | https://doi.org/10.1021/jacs.1c02121 |
Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation
| Authors | Jin, Shuaijiang, Roberto J. Brea, Rudd, Andrew K., Moon, Stuart P., Pratt, Matthew R., Devaraj, Neal K. |
| Journal | NATURE COMMUNICATIONS Vol. 11 Num. 1 |
| DOI | https://doi.org/10.1038/s41467-020-16595-w |
Temperature-Dependent Reversible Morphological Transformations in N-Oleoyl beta-D-Galactopyranosylamine
| Authors | Johnson, Mai, Bhattacharya, Ahanjit, Roberto J. Brea, Podolsky, Kira A., Devaraj, Neal K. |
| Journal | JOURNAL OF PHYSICAL CHEMISTRY B Vol. 124 Num. 26 (pages 5426 to 5433) |
| DOI | https://doi.org/10.1021/acs.jpcb.0c01410 |
Lipids: chemical tools for their synthesis, modification, and analysis
| Authors | Flores, Judith, White, Brittany M., Roberto J. Brea, Baskin, Jeremy M., Devaraj, Neal K. |
| Journal | CHEMICAL SOCIETY REVIEWS Vol. 49 Num. 14 (pages 4602 to 4614) |
| DOI | https://doi.org/10.1039/d0cs00154f |
Lipid sponge droplets as programmable synthetic organelles
| Authors | Bhattacharya, Ahanjit, Niederholtmeyer, Henrike, Podolsky, Kira A., Bhattacharya, Rupak, Song, Jing-Jin, Roberto J. Brea, Tsai, Chu-Hsien, Sinha, Sunil K., Devaraj, Neal K. |
| Journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 117 Num. 31 (pages 18206 to 18215) |
| DOI | https://doi.org/10.1073/pnas.2004408117 |
Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles
| Authors | Vora, Hetika D., Johnson, Mai, Roberto J. Brea, Rudd, Andrew K., Devaraj, Neal K. |
| Journal | ACS CHEMICAL BIOLOGY Vol. 15 Num. 8 (pages 2079 to 2086) |
| DOI | https://doi.org/10.1021/acschembio.0c00222 |
Single-Chain beta-D-Glycopyranosylamides of Unsaturated Fatty Acids: Self-Assembly Properties and Applications to Artificial Cell Development
| Authors | Bhattacharya, Ahanjit, Roberto J. Brea, Song, Jing-Jin, Bhattacharya, Rupak, Sinha, Sunil K., Devaraj, Neal K. |
| Journal | JOURNAL OF PHYSICAL CHEMISTRY B Vol. 123 Num. 17 (pages 3711 to 3720) |
| DOI | https://doi.org/10.1021/acs.jpcb.9b01055 |
A minimal biochemical route towards de novo formation of synthetic phospholipid membranes
| Authors | Bhattacharya, Ahanjit, Roberto J. Brea, Niederholtmeyer, Henrike, Devaraj, Neal K. |
| Journal | NATURE COMMUNICATIONS Vol. 10 |
| DOI | https://doi.org/10.1038/s41467-018-08174-x |
In Situ Lipid Membrane Formation Triggered by Intramolecular Photoinduced Electron Transfer
| Authors | Enomoto, Takafumi, Roberto J. Brea, Bhattacharya, Ahanjit, Devaraj, Neal K. |
| Journal | LANGMUIR Vol. 34 Num. 3 (pages 750 to 755) |
| DOI | https://doi.org/10.1021/acs.langmuir.7b02783 |
Biomimetic Generation and Remodeling of Phospholipid Membranes by Dynamic Imine Chemistry
| Authors | Seoane, Andres, Roberto J. Brea, Fuertes, Alberto, Podolsky, Kira A., Devaraj, Neal K. |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 140 Num. 27 (pages 8388 to 8391) |
| DOI | https://doi.org/10.1021/jacs.8b04557 |
Highly Stable Artificial Cells from Galactopyranose-Derived Single-Chain Amphiphiles
| Authors | Roberto J. Brea, Bhattacharya, Ahanjit, Bhattacharya, Rupak, Song, Jing-jin, Sinha, Sunil K., Devaraj, Neal K. |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 140 Num. 50 (pages 17356 to 17360) |
| DOI | https://doi.org/10.1021/jacs.8b09388 |
Amphiphile-Mediated Depalmitoylation of Proteins in Living Cells
| Authors | Rudd, Andrew K., Roberto J. Brea, Devaraj, Neal K. |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 140 Num. 50 (pages 17374 to 17378) |
| DOI | https://doi.org/10.1021/jacs.8b10806 |
Spontaneous Phospholipid Membrane Formation by Histidine Ligation
| Authors | Roberto J. Brea, Bhattacharya, Ahanjit, Devaraj, Neal K. |
| Journal | SYNLETT Vol. 28 Num. 1 (pages 108 to 112) |
| DOI | https://doi.org/10.1055/s-0036-1588634 |
In Situ Reconstitution of the Adenosine A(2A) Receptor in Spontaneously Formed Synthetic Liposomes
| Authors | Roberto J. Brea, Cole, Christian M., Lyda, Brent R., Ye, Libin, Prosser, R. Scott, Sunahara, Roger K., Devaraj, Neal K. |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 139 Num. 10 (pages 3607 to 3610) |
| DOI | https://doi.org/10.1021/jacs.6b12830 |
Tension Promoted Sulfur Exchange for Cellular Delivery
| Authors | Roberto J. Brea, Devaraj, Neal K. |
| Journal | ACS CENTRAL SCIENCE Vol. 3 Num. 6 (pages 524 to 525) |
| DOI | https://doi.org/10.1021/acscentsci.7b00178 |
Continual reproduction of self-assembling oligotriazole peptide nanomaterials
| Authors | Roberto J. Brea, Devaraj, Neal K. |
| Journal | NATURE COMMUNICATIONS Vol. 8 |
| DOI | https://doi.org/10.1038/s41467-017-00849-1 |
De novo vesicle formation and growth: an integrative approach to artificial cells
| Authors | Bhattacharya, Ahanjit, Roberto J. Brea, Devaraj, Neal K. |
| Journal | CHEMICAL SCIENCE Vol. 8 Num. 12 (pages 7912 to 7922) |
| DOI | https://doi.org/10.1039/c7sc02339a |
Nonenzymatic biomimetic remodeling of phospholipids in synthetic liposomes
| Authors | Roberto J. Brea, Rudd, Andrew K., Devaraj, Neal K. |
| Journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 113 Num. 31 (pages 8589 to 8594) |
| DOI | https://doi.org/10.1073/pnas.1605541113 |
Towards Self-Assembled Hybrid Artificial Cells: Novel Bottom-Up Approaches to Functional Synthetic Membranes
| Authors | Roberto J. Brea, Hardy, Michael D., Devaraj, Neal K. |
| Journal | CHEMISTRY-A EUROPEAN JOURNAL Vol. 21 Num. 36 (pages 12564 to 12570) |
| DOI | https://doi.org/10.1002/chem.201501229 |
Spontaneous Reconstitution of Functional Transmembrane Proteins During Bioorthogonal Phospholipid Membrane Synthesis
| Authors | Cole, Christian M., Roberto J. Brea, Kim, Young Hun, Hardy, Michael D., Yang, Jerry, Devaraj, Neal K. |
| Journal | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 54 Num. 43 (pages 12738 to 12742) |
| DOI | https://doi.org/10.1002/anie.201504339 |
In Situ Vesicle Formation by Native Chemical Ligation
| Authors | Roberto J. Brea, Cole, Christian M., Devaraj, Neal K. |
| Journal | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 53 Num. 51 (pages 14102 to 14105) |
| DOI | https://doi.org/10.1002/anie.201408538 |
Self-assembling properties of all gamma-cyclic peptides containing sugar amino acid residues
| Authors | Guerra, Arcadio, Roberto J. Brea, Amorin, Manuel, Luis Castedo, Juan R. Granja |
| Journal | ORGANIC & BIOMOLECULAR CHEMISTRY Vol. 10 Num. 44 (pages 8762 to 8766) |
| DOI | https://doi.org/10.1039/c2ob26612a |
Regioisomeric Control Induced by DABCO Coordination to Rotatable Self-Assembled Bis- and Tetraporphyrin alpha,gamma-Cyclic Octapeptide Dimers
| Authors | Hernandez-Eguia, Laura P., Roberto J. Brea, Luis Castedo, Ballester, Pablo, Juan R. Granja |
| Journal | CHEMISTRY-A EUROPEAN JOURNAL Vol. 17 Num. 4 (pages 1220 to 1229) |
| DOI | https://doi.org/10.1002/chem.201002271 |
Highly Efficient and Directional Homo- and Heterodimeric Energy Transfer Materials Based on Fluorescently Derivatized alpha,gamma-Cyclic Octapeptides
| Authors | Roberto J. Brea, María Jesus Perez-Alvite, Michele Panciera, Manuel Mosquera, Luis Castedo, Juan R. Granja |
| Journal | CHEMISTRY-AN ASIAN JOURNAL Vol. 6 Num. 1 (pages 110 to 121) |
| DOI | https://doi.org/10.1002/asia.201000545 |
Towards functional bionanomaterials based on self-assembling cyclic peptide nanotubes
| Authors | Roberto J. Brea, Reiriz, Cesar, Juan R. Granja |
| Journal | CHEMICAL SOCIETY REVIEWS Vol. 39 Num. 5 (pages 1448 to 1456) |
| DOI | https://doi.org/10.1039/b805753m |
alpha,gamma-Peptide Nanotube Templating of One-Dimensional Parallel Fullerene Arrangements
| Authors | Reiriz, Cesar, Roberto J. Brea, Arranz, Rocio, Carrascosa, Jose L., Garibotti, Alejandra, Manning, Brendan, Valpuesta, Jose M., Eritja, Ramon, Luis Castedo, Juan R. Granja |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 131 Num. 32 (pages 11335+ to 11337) |
| DOI | https://doi.org/10.1021/ja904548q |
Nanotubos ciclopeptídicos: un camino alternativo para la preparación prêt-à-porter de estructuras tubulares diseñadas a medida
| Authors | Brea, Roberto J., Granja, Juan R. |
| Journal | ANALES DE LA REAL SOCIEDAD ESPAÑOLA DE QUÍMICA Vol. 104 Num. 4 (pages 257 to 264) |
Controlling multiple fluorescent signal output in cyclic peptide-based supramolecular systems
| Authors | Roberto J. Brea, Vazquez, M. Eugenio, Manuel Mosquera, Luis Castedo, Juan R. Granja |
| Journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Vol. 129 Num. 6 (pages 1653 to 1657) |
| DOI | https://doi.org/10.1021/ja066885h |
Electron transfer in Me-blocked heterodimeric alpha,gamma-peptide nanotubular donor-acceptor hybrids
| Authors | Roberto J. Brea, Luis Castedo, Juan R. Granja, Herranz, M. Angeles, Sanchez, Luis, Martin, Nazario, Seitz, Wolfgang, Guldi, Dirk M. |
| Journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 104 Num. 13 (pages 5291 to 5294) |
| DOI | https://doi.org/10.1073/pnas.0609506104 |
Large-diameter self-assembled dimers of alpha,gamma-cyclic peptides, with the nanotubular solid-state structure of cyclo-{[}(L-Leu-D-N-Me-gamma-Acp)(4-)] 4CHCl(2)COOH
| Authors | Roberto J. Brea, Luis Castedo, Juan R. Granja |
| Journal | CHEMICAL COMMUNICATIONS Num. 31 (pages 3267 to 3269) |
| DOI | https://doi.org/10.1039/b703659k |
Self-assembling cyclic gamma,alpha-tetrapeptides
| Authors | Amorin, M, Brea, RJ, Luis Castedo, Granja, JR |
| Journal | HETEROCYCLES Vol. 67 Num. 2 (pages 575 to 583) |
Synthesis of omega-(hetero)arylalkynylated alpha-amino acid by sonogashira-type reactions in aqueous media
| Authors | Roberto J. Brea, Lopez-Deber, M. Pilar, Luis Castedo, Granja, Juan R. |
| Journal | JOURNAL OF ORGANIC CHEMISTRY Vol. 71 Num. 20 (pages 7870 to 7873) |
| DOI | https://doi.org/10.1021/jo061300n |
Methyl-blocked dimeric alpha,gamma-peptide nanotube segments: Formation of a peptide heterodimer through backbone-backbone interactions
| Authors | Brea, RJ, Amorin, M, Luis Castedo, Granja, JR |
| Journal | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 44 Num. 35 (pages 5710 to 5713) |
| DOI | https://doi.org/10.1002/anie.200501555 |
The smallest alpha,gamma-peptide nanotubulet segments: Cyclic alpha,gamma-tetrapeptide dimers
| Authors | Amorin, M, Brea, RJ, Luis Castedo, Granja, JR |
| Journal | ORGANIC LETTERS Vol. 7 Num. 21 (pages 4681 to 4684) |
| DOI | https://doi.org/10.1021/ol0518885 |
Supramolecular assembly and mesophase behavior of glycopyranose-derived single-chain amphiphiles
| Authors | Bhattacharya, Ahanjit. Brea, Roberto J. |
| Book |
Molecular assemblies: characterization and applications (ACS Symposium Series #1355) Publishing: American Chemical Society. ISBN: 978-0-841-29888-0 |
| Pages | From 15 to 30 |
Diels-Alder and inverse Diels-Alder reactions
| Authors | Brea, Roberto J.. Devaraj, Neal K. |
| Book |
Chemoselective and bioorthogonal ligation reactions: concepts and applications Publishing: Wiley-VCH. ISBN: 978-3-527-33436-0 |
| Pages | From 67 to 95 |
Self-assembling cyclic peptide-based nanomaterials
| Authors | Brea, Roberto J. |
| Book |
Ideas in Chemistry and Molecular Sciences: Advances in Nanotechnology, Materials and Devices Publishing: Wiley-VCH. ISBN: 978-3-527-32543-6 |
| Pages | From 3 to 22 |
Self-assembly of cyclic peptides in hydrogen-bonded nanotubes
| Authors | Brea, Roberto J.. Granja, Juan R. |
| Book |
Dekker Encyclopedia of Nanoscience and Nanotechnology Publishing: Marcel Dekker, inc.. ISBN: 978-0-824-75046-6 |
| Pages | From 3439 to 3457 |
Chemoenzymatic generation of functional synthetic cells
XXXVIII Reunión Bienal de la Real Sociedad Española de Química
International
| Authors | Brea, Roberto J. |
| Place | Granada (España) |
Non-lamellar lipid structures as artificial organelles
264th ACS National Meeting & Exposition
International
| Authors | Sinha, Sunil K., Devaraj, Neal K., Joseph, Simpson, Seifert, Soenke, Edwards, Madison, Pandey, Sudip, Salvador-Castell, Marta, Brea, Roberto J., Moinpour, Mahta, Fracassi, Alessandro |
| Place | Chicago (Estados Unidos) |
De novo construction of functional synthetic cells
264th ACS National Meeting & Exposition
International
| Authors | Lomba-Riego, Lucía, Calvino-Sanles, Esther, Pérez, José M., Brea, Roberto J. |
| Place | Chicago (Estados Unidos) |
Chemoselective construction of dynamic synthetic cells
261st ACS National Meeting & Exposition
International
| Authors | Brea, Roberto J., Devaraj, Neal K. |
| Place | San Diego (Estados Unidos) |
Chemoselective generation of dynamic synthetic cells
SynCell 2021
International
| Authors | Brea, Roberto J., Devaraj, Neal K. |
| Place | Virtual (Estados Unidos) |
Direct depalmitoylation of NRAS as a therapeutic strategy
258th ACS National Meeting & Exposition
International
| Authors | Vora, Hetika, Johnson, Mai, Brea, Roberto J., Rudd, Andrew K., Devaraj, Neal K. |
| Place | San Diego (Estados Unidos) |
Galactosylated nanovesicles for liver targeting
258th ACS National Meeting & Exposition
International
| Authors | Johnson, Mai, Bhattacharya, Ahanjit, Brea, Roberto J., Devaraj, Neal K. |
| Place | San Diego (Estados Unidos) |
Small molecules for functional protein depalmitoylation
258th ACS National Meeting & Exposition
International
| Authors | Rudd, Andrew K., Brea, Roberto J., Devaraj, Neal K. |
| Place | San Diego (Estados Unidos) |
Construction of artificial cells from galactopyranose-derived single-chain amphiphiles
258th ACS National Meeting & Exposition
International
| Authors | Brea, Roberto J., Bhattacharya, Ahanjit, Devaraj, Neal K. |
| Place | San Diego (Estados Unidos) |
Acceleration of native chemical ligation
255th ACS National Meeting & Exposition
International
| Authors | Jin, Shuaijiang, Brea, Roberto J., Devaraj, Neal K. |
| Place | New Orleans (Estados Unidos) |
Functional characterization of GPCRs in synthetic membranes using in situ lipid synthesis for protein reconstitution technology
255th ACS National Meeting & Exposition
International
| Authors | Podolsky, Kira, Brea, Roberto J., Devaraj, Neal K. |
| Place | New Orleans (Estados Unidos) |
In situ synthesis of dynamic phospholipid membranes
255th ACS National Meeting & Exposition
International
| Authors | Seoane, Andrés, Brea, Roberto J., Fuertes, Alberto, Devaraj, Neal K. |
| Place | New Orleans (Estados Unidos) |
Continual reproduction of self-assembling peptide nanomaterials
255th ACS National Meeting & Exposition
International
| Authors | Brea, Roberto J., Devaraj, Neal K. |
| Place | New Orleans (Estados Unidos) |
Chemoselective construction of biomimetic membranes
255th ACS National Meeting & Exposition
International
| Authors | Brea, Roberto J., Devaraj, Neal K. |
| Place | New Orleans (Estados Unidos) |
Chemoselective construction of functional synthetic membranes
Systems Chemistry, from concepts to conception (Gordon Research Conference)
International
| Authors | Brea, Roberto J., Devaraj, Neal K. |
| Place | Newry (Estados Unidos) |
Chemoselective construction of artificial lipid membranes
Nanoscale Horizons Symposium
International
| Authors | Brea, Roberto J., Devaraj, Neal K. |
| Place | La Jolla (Estados Unidos) |
In situ synthesis of lipids: de novo construction of functional artificial cells and chemoselective depalmitoylation of proteins in living cells
IX International Young Investigator Meeting
International
| Authors | Brea, Roberto J. |
| Place | Coruña, A (España) |
Biomimetic construction of phospholipid membranes
253rd ACS National Meeting & Exposition
International
| Authors | Brea, Roberto J., Cole, Christian M., Rudd, Andrew K., Devaraj, Neal K. |
| Place | San Francisco (Estados Unidos) |
Chemoselective assembly and modification of lipids for use in model and live-cell systems
254th ACS National Meeting & Exposition
International
| Authors | Rudd, Andrew K., Brea, Roberto J., Devaraj, Neal K. |
| Place | Washington (Estados Unidos) |
De novo construction of synthetic phospholipid membranes
Third Annual Chemistry & Biochemistry Postdoctoral Research Symposium
Local
| Authors | Brea, Roberto J. |
| Place | La Jolla (Estados Unidos) |
Spontaneous formation and remodeling of synthetic membranes
251st ACS National Meeting & Exposition
International
| Authors | Brea, Roberto J., Rudd, Andrew K., Devaraj, Neal K. |
| Place | San Diego (Estados Unidos) |
Spontaneous generation of artificial lipid membranes
23rd IUPAC Conference on Physical Organic Chemistry
International
| Authors | Brea, Roberto J., Cole, Christian M., Rudd, Andrew K., Devaraj, Neal K. |
| Place | Sydney (Australia) |
Bioorthogonal construction of artificial lipid membranes
16th HFSP Awardees Meeting
International
| Authors | Brea, Roberto J., Cole, Christian M., Devaraj, Neal K. |
| Place | Singapur (Singapur) |
In situ phospholipid membrane formation by native chemical ligation
15th HFSP Awardees Meeting
International
| Authors | Brea, Roberto J., Cole, Christian M., Devaraj, Neal K. |
| Place | La Jolla (Estados Unidos) |
Spontaneous phospholipid membrane generation by native chemical ligation
XXXV Reunión Bienal de la Real Sociedad Española de Química
International
| Authors | Brea, Roberto J., Cole, Christian M., Devaraj, Neal K. |
| Organization | Real Soceidad Española de Química (RSEQ) |
| Place | Coruña, A (España) |
Spontaneous reconstitution of functional transmembrane proteins during bioorthogonal phospholipid membrane synthesis
Pacifichem 2015
International
| Authors | Cole, Christian M., Brea, Roberto J., Hardy, Michael D., Kim, Young Hun, Yang, Jerry, Devaraj, Neal K. |
| Place | Honolulu (Estados Unidos) |
Spontaneous phospholipid membrane formation by native chemical ligation
Pacifichem 2015
International
| Authors | Brea, Roberto J., Cole, Christian M., Devaraj, Neal K. |
| Place | Honolulu (Estados Unidos) |
Sugar-based alfa,gamma-cyclic peptide nanotubes
International Workshop on Molecular Materials
International
| Authors | Guerra, Arcadio, Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Place | Sanxenxo (España) |
Self-assembled molecular containers based on alfa,gamma-cyclic peptides
International Workshop on Molecular Materials
International
| Authors | Ozores, Haxel Lionel, Panciera, Michele, Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Place | Sanxenxo (España) |
Reversible encapsulation systems based on alfa,gamma-cyclic peptides
III School on Organometallic Chemistry Marcial Moreno Mañas
International
| Authors | Ozores, Haxel Lionel, Brea, Roberto J., Amorín, Manuel, Castedo, Luis, Granja, Juan R. |
| Place | Oviedo (España) |
Supramolecular control of porphyrin derivatized alfa,gamma-cyclic peptides
International Conference on Pure and Applied Chemistry
International
| Authors | Brea, Roberto J., Hernández, Laura P., Castedo, Luis, Ballester, Pablo, Granja, Juan R. |
| Place | Balaclava (Mauricio) |
New fullerene array based on peptide nanotubes
240th ACS National Meeting & Exposition
International
| Authors | Reiriz, César, Brea, Roberto J., Granja, Juan R. |
| Place | Boston (Estados Unidos) |
Covalent-linked self-assembled alfa,gamma-cyclic peptides
7th ERA-Flash Conference on Bioinspired Chemistry
International
| Authors | Guerra, Arcadio, Pérez, María Jesús, Brea, Roberto J., García-Fandiño, Rebeca, Granja, Juan R. |
| Place | Santiago de Compostela (España) |
Autoensamblaje molecular de alfa,gamma-ciclopéptidos: de dímeros a nanotubos peptídicos
XXXII Reunión Bienal de la Real Sociedad Española de Química
National
| Authors | Reiriz, César, Brea, Roberto J., Pérez, María Jesús, Castedo, Luis, Granja, Juan R. |
| Organization | Real Sociedad Española de Química |
| Place | Oviedo (España) |
Organic porous materials based on alfa,gamma-cyclic peptides
Conference on Supramolecular Approaches to Catalysis
International
| Authors | Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Place | Barcelona (España) |
Peptide derivatization by Sonogashira type reaction in aqueous media
XI Encuentro Peptídico Ibérico
International
| Authors | Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Place | Santiago de Compostela (España) |
Sugar derivatives for self-assembling gamma-cyclic peptides
30th European Peptide Symposium
International
| Authors | Brea, Roberto J., Silva, Luis F., Reiriz, César, Amorín, Manuel, Granja, Juan R. |
| Place | Helsinki (Finlandia) |
Supramolecular donor-acceptor systems based on alfa,gamma-cyclic peptides
7th Spanish-Italian Symposium on Organic Chemistry (SISOC7)
International
| Authors | Pérez, María Jesús, Panciera, Michele, Castedo, Luis, Granja, Juan R., Brea, Roberto J. |
| Place | Oviedo (España) |
From structure to application of alfa,gamma-cyclic peptides
7th Spanish-Italian Symposium on Organic Chemistry (SISOC7)
International
| Authors | Brea, Roberto J., Reiriz, César, Amorín, Manuel, Pérez, María Jesús, Castedo, Luis, Granja, Juan R. |
| Place | Oviedo (España) |
Novel properties of cyclic octapeptides containing gamma-amino acids
2nd European Chemistry Congress
International
| Authors | Brea, Roberto J., Pérez, María Jesús, Panciera, Michele, Guerra, Arcadio, Castedo, Luis, Granja, Juan R. |
| Place | Turín (Italia) |
Sistemas supramoleculares dador-aceptor basados en alfa,gamma-ciclopéptidos
V Simposio Investigadores Jóvenes RSEQ - Sigma Aldrich
International
| Authors | Granja, Juan R., Castedo, Luis, Brea, Roberto J. |
| Place | Santiago de Compostela (España) |
Controlling fluorescent signal in self-assembling alfa,gamma-cyclic peptides
11th European Symposium on Organic Reactivity
International
| Authors | Pérez, María Jesús, Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Place | Faro (Portugal) |
Bio-inspired electron-donor-acceptor hybrids
XXIII International Conference on Photochemistry
International
| Authors | Seitz, Wolfgang, Brea, Roberto J., Granja, Juan R., Martín, Nazario, Torres, Tomás, Sessler, Jonathan L., Guldi, Dirk M. |
| Place | Colonia (Alemania) |
Synthesis of omega-aryl-alkynylamino acid derivatives by Sonogashira-s reaction in aqueous media
X Encuentro Peptídico Ibérico
International
| Authors | Brea, Roberto J., Granja, Juan R. |
| Place | Zaragoza (España) |
alfa,gamma-Ciclopéptidos: formación de heterodímeros
X Encuentro Peptídico Ibérico
International
| Authors | Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Place | Zaragoza (España) |
Towards functional self-assembling cyclic alfa,gamma-peptides
1st European Chemistry Congress
International
| Authors | Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Organization | European Association for Chemical and Molecular Sciences (EuCheMS) |
| Place | Budapest (Hungría) |
Hacia el diseño de componentes electrónicos moleculares basados en nanotubos peptídicos
XXI Reunion Bienal de Química Orgánica
National
| Authors | Brea, Roberto J., Pérez, María Jesús, Vázquez, M. Eugenio, Castedo, Luis, Granja, Juan R. |
| Place | Valladolid (España) |
Formación de heterodímeros alfa,gamma-peptídicos
XXX Reunión Bienal de la Real Sociedad Española de Química
International
| Authors | Brea, Roberto J., Amorín, Manuel, Castedo, Luis, Granja, Juan R. |
| Place | Lugo (España) |
Formation of alfa,gamma-peptide heterodimeric nanotubulets through backbone-backbone interactions
Molecular Architectures and Systems
International
| Authors | Brea, Roberto J., Amorín, Manuel, Castedo, Luis, Granja, Juan R. |
| Place | Obernai (Francia) |
Self-assembling alfa,gamma-cyclopeptide tubulets
7th International Symposium on Biomolecular Chemistry
International
| Authors | Brea, Roberto J., Amorín, Manuel, Granja, Juan R. |
| Place | Sheffield (Reino Unido) |
Peptide modification by Sonogashira type reaction in aqueous media
5th Spanish-Italian Symposium on Organic Chemistry
International
| Authors | Brea, Roberto J., Granja, Juan R. |
| Place | Santiago de Compostela (España) |
alfa,gamma-cyclopeptides capable of forming peptidic nanotubes: the structural and thermodynamic basis
38th National Organic Symposium
International
| Authors | Amorín, Manuel, Brea, Roberto J., Castedo, Luis, Granja, Juan R. |
| Place | Bloomington (Estados Unidos) |
Synthesis of omega-aryl-alkynylamino acids by Sonogashira types of reaction in aqueous media
38th National Organic Symposium
International
| Authors | Brea, Roberto J., Granja, Juan R. |
| Place | Bloomington (Estados Unidos) |
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