Dr. Francisco Javier Blanco García  

Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis

Generation of Mesenchymal Cell Lines Derived from Aged Donors

Neuropathic pain in the IMI-Open APPROACH knee osteoarthritis cohort: prevalence and phenotyping

Prevalence of symptomatic osteoarthritis in Spain: EPISER2016 study

Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort

Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes

Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis

Dietary habits in patients with fibromyalgia: a cross-sectional study

Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort

Oleate Prevents Palmitate-Induced Mitochondrial Dysfunction in Chondrocytes

The Phenotype of Axial Spondyloarthritis: Is It Dependent on HLA-B27 Status?

One-Year, Efficacy and Safety Open Label Study, with a Single Injection of a New Hyaluronan for Knee OA: The SOYA Trial

A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative

Mitochondrial DNA impact on joint damaged process in a conplastic mouse model after being surgically induced with osteoarthritis

Endorsement of the OMERACT core domain set for shared decision making interventions in rheumatology trials: Results from a multi-stepped consensus-building approach

Food groups associated with immune-mediated inflammatory diseases: a Mendelian randomization and disease severity study

Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

Optical Biomarkers for the Diagnosis of Osteoarthritis through Raman Spectroscopy: Radiological and Biochemical Validation Using Ex Vivo Human Cartilage Samples

Subcutaneous tanezumab for osteoarthritis: Is the early improvement in pain and function meaningful and sustained?

Relationship Between the Dynamics of Telomere Loss in Peripheral Blood Leukocytes From Knee Osteoarthritis Patients and Mitochondrial DNA Haplogroups

Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes Secretome of synoviocytes induces chondrocyte damage

Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids

Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging

Autophagy Activation by Resveratrol Reduces Severity of Experimental Rheumatoid Arthritis

Relationship between motion, using the GaitSmart (TM) system, and radiographic knee osteoarthritis: an explorative analysis in the IMI-APPROACH cohort

Targeted phospholipidomic analysis of synovial fluid as a tool for osteoarthritis deep phenotyping

Genetic biomarkers in osteoarthritis: a quick overview.

Generation of a human control iPS cell line (ESi080-A) from a donor with no rheumatic diseases

Versatility of Induced Pluripotent Stem Cells (iPSCs) for Improving the Knowledge on Musculoskeletal Diseases

Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts

Hydrogen Sulfide Biosynthesis Is Impaired In The Osteoarthritic Joint

Effect Of Balneotherapy In Sulphurous Water On An In Vivo Model Murine Of Osteoarthritis

Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis

Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross-Sectional Study

Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease

Amentadione from the Alga Cystoseira usneoides as a Novel Osteoarthritis Protective Agent in an Ex Vivo Co-Culture OA Model

Association of apolipoprotein B/apolipoprotein Al ratio and cardiovascular events in rheumatoid arthritis: results of the CARMA study

Precision medicine: something is changing in rheumatology

IL6/sIL6R regulates TNF alpha-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

Mitochondrial DNA in osteoarthritis disease

Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?

Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers

Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis

Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases

Molecular analysis of the destruction of articular joint tissues by Raman spectroscopy

Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

Immortalizing Mesenchymal Stromal Cells from Aged Donors While Keeping Their Essential Features

An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis

RGD-Dendrimer-Poly(L-lactic) Acid Nanopatterned Substrates for the Early Chondrogenesis of Human Mesenchymal Stromal Cells Derived from Osteoarthritic and Healthy Donors

Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis

Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period

Impaired Metabolic Flexibility in the Osteoarthritis Process: A Study on Transmitochondrial Cybrids

Cartilage Metabolism, Mitochondria, and Osteoarthritis

Fracture risk assessment in the general population in Spain by FRAX (R) algorithm. EPISER2016 study

All-Trans Retinoic Acid Inhibits Migration and Invasiveness of Rheumatoid Fibroblast-Like Synoviocytes

Impact of Prevalence Ratios of Chondroitin Sulfate (CS)-4 and-6 Isomers Derived from Marine Sources in Cell Proliferation and Chondrogenic Differentiation Processes

Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: A prospective study

Mitochondrial Genetics and Epigenetics in Osteoarthritis

Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin

Wnt y RUNX2 median la degradación del cartílago por osteoartritis derivados de fibroblastos sinoviales ADAMTS-7 y -12.

Efectos antiinflamatorios de los nuevos liberados de plasma rico en plaquetas en los condrocitos y cartílago osteoartríticos de rodilla in vitro.

Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis

Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis

Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology

Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors A potential SNP association with response to etanercept

Platelet-rich plasma in osteoarthritis treatment: review of current evidence

Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets

A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1¿/ß Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes.

Mitochondrial DNA haplogroups influence the risk of aortic stenosis.

2018 update of the EULAR recommendations for the management of hand osteoarthritis

Src and podoplanin forge a path to destruction

Usefulness of Mesenchymal Cell Lines for Bone and Cartilage Regeneration Research

Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative

Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis

Analysis of Endogenous Peptides Released from Osteoarthritic Cartilage Unravels Novel Pathogenic Markers

A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

Mining the Proteome Associated with Rheumatic and Autoimmune Diseases

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

The addition of albumin improves Schwann cells viability in nerve cryopreservation

INDUCED PLURIPOTENT STEM CELL FOR CARTILAGE REPAIR: CURRENT STATUS AND FUTURE PERSPECTIVES

Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations

Incident hand OA is strongly associated with reduced peripheral blood leukocyte telomere length

In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis

Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis

Efficacy of tocilizumab monotherapy after response to combined tocilizumab and methotrexate in patients with rheumatoid arthritis: the randomised JUST-ACT study

Clinical, Patient-Reported, and Ultrasound Outcomes from an Open-Label, 12-week Observational Study of Certolizumab Pegol in Spanish Patients with Rheumatoid Arthritis with or without Prior Anti-TNF Exposure

Osteoarthritis and atherosclerosis in joint disease

Expert Recommendations on the Interleukin 6 Blockade in Patients with Rheumatoid Arthritis

Mitochondria and mitophagy: biosensors for cartilage degradation and osteoarthritis

Intraneural IFG-1 in Cryopreserved Nerve Isografts Increase Neural Regeneration and Functional Recovery in the Rat Sciatic Nerve

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes

Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis

Early and sustained efficacy with apremilast monotherapy in biological-naïve patients with psoriatic arthritis: a phase IIIB, randomised controlled trial (ACTIVE).

Recommendations for the use of parenteral methotrexate in rheumatic diseases

What did we learn from 'omics' studies in osteoarthritis

Ovine Mesenchymal Stromal Cells: Morphologic, Phenotypic and Functional Characterization for Osteochondral Tissue Engineering

Human amniotic mesenchymal stromal cells as favourable source for cartilage repair.

Hydrogen Sulfide and Inflammatory Joint Diseases

Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells

The mitocondrial inhibitor oligomycin induces an inflammatory response in the rat knee Joint

Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study.

A replication study and meta-analysis of mitochondrial DNA variants in the radiographic progression of knee osteoarthritis

Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro

BIODISTRIBUTION AND IMMUNOGENICITY OF ALLOGENEIC MESENCHYMAL STEM CELLS IN A RAT MODEL OF INTRAARTICULAR CHONDROCYTE XENOTRANSPLANTATION

CD105+ mesenchymal stem cells migrate into osteoarthritis joint: an animal model.

Improved control over MSCs behavior within 3D matrices by using different cell loads in both in vitro and in vivo environments

The role of osmolarity adjusting agents in the regulation of encapsulated cell behavior to provide a safer and more predictable delivery of therapeutics

Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication

An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis

MALDI mass spectrometry imaging in rheumatic diseases. Biochim Biophys Acta Proteins Proteom.

Hif-1¿ Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress

Cardiovascular disease in immune-mediated inflammatory diseases: A cross-sectional analysis of 6 cohorts

Secukinumab in Active Rheumatoid Arthritis: A Phase III Randomized, Double-Blind, Active Comparator- and Placebo-Controlled Study

Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies.

Defining the proteomic landscape of rheumatoid arthritis: progress and prospective clinical applications

Recommendations by the Spanish Society of Rheumatology for the management of patients diagnosed with rheumatoid arthritis who cannot be treated with methotrexate

Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project.

Discovery of circulating proteins associated to knee radiographic osteoarthritis

Hybrid Alginate¿Protein-Coated Graphene Oxide Microcapsules Enhance the Functionality of Erythropoietin Secreting C2C12 Myoblasts

A multicentric study to evaluate the use of relative retention times in targeted proteomics

Multiplexed mass spectrometry monitoring of biomarker candidates for osteoarthritis

Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With Knee Osteoarthritis: A Six-Month Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mass spectrometry imaging: a novel technology in rheumatology

Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial

3, 3',5-Triiodo-L-Thyronine Increases In Vitro Chondrogenesis of Mesenchymal Stem Cells from Human Umbilical Cord Stroma Through SRC2

Differentiation of human mesenchymal stromal cells cultured on collagen sponges for cartilage repair

Resveratrol lowers synovial hyperplasia, inflammatory markers, and oxidative damage in an acute antigen-induced arthritis model

Brief Report: European Mitochondrial Haplogroups Impact on Liver Fibrosis Progression Among HCV and HIV/HCV-Coinfected Patients From Northwest Spain

Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation

Generating Rho-0 Cells Using Mesenchymal Stem Cell Lines

A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis

Specific premature epigenetic aging of cartilage in osteoarthritis

Urine metabolome profiling of immune-mediated inflammatory diseases

Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis

A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis

Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3)

Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study

Effectiveness of Tapentadol Prolonged Release (PR) Compared with Oxycodone/Naloxone PR for the Management of Severe Chronic Low Back Pain with a Neuropathic Component: A Randomized, Controlled, Open-Label, Phase 3b/4 Study

Secretome analysis of human articular chondrocytes unravels catabolic effects of nicotine on the joint

Translation of clinical problems in osteoarthritis into pathophysiological research goals

A methodological approach based on gold-nanoparticles followed by matrix assisted laser desorption ionization time of flight mass spectrometry for the analysis of urine profiling of knee osteoarthritis

Insulin decreases autophagy and leads to cartilage degradation

A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis

Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis

Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Alternative protocols to induce chondrogenic differentiation: Transforming Growth Factor-ß superfamily

iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis

Mitochondrial DNA haplogroups modulate the radiographic progression of Spanish patients with osteoarthritis

Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis

Long-term safety, efficacy, and quality of life in patients with juvenile idiopathic arthritis treated with intravenous abatacept for up to seven years

The Spanish biology/disease initiative within the human proteome project: Application to rheumatic diseases

Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

Lessons from the proteomic study of osteoarthritis

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use

Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis

Improved prediction of knee osteoarthritis progression by genetic polymorphisms: the Arthrotest Study

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis

Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes

Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study

Protein classification and distribution in osteoarthritic human synovial tissue by matrix-assisted laser desorption ionization mass spectrometry imaging

Characterization of lipidic markers of chondrogenic differentiation using mass spectrometry imaging

Effect of the physicochemical properties of pure or chitosan-coated poly(L-lactic acid)scaffolds on the chondrogenic differentiation of mesenchymal stem cells from osteoarthritic patients

Integrating medical and research information: a big data approach

Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis

Influence of flap prefabrication on seeding of subcutaneously injected mesenchymal stem cells in microvascular beds in rats

Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1ß-stimulated human articular chondrocytes.

Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes

Individual telomere length decay in patients with spondyloarthritis

Quantitative proteomic profiling of human articular cartilage degradation in osteoarthritis

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

Osteoarthritis year in review 2014: we need more biochemical biomarkers in qualification phase

Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis Data from the Osteoarthritis Initiative (OAI)

Analysis of autoantibody profiles in osteoarthritis using comprehensive protein array concepts

Genotypic tropism testing in proviral DNA to guide maraviroc initiation in aviremic subjects: 48-week analysis of the PROTEST study

Multifunctional hydrogel-based scaffold for improving the functionality of encapsulated therapeutic cells and reducing inflammatory response

Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case-control study

Editorial: Is it time for epigenetics in osteoarthritis?

Sequential depletion coupled to C18 sequential extraction as a rapid tool for human serum multiple profiling

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine

Cryoconservation of peptide extracts from trypsin digestion of proteins for proteomic analysis in a hospital biobank facility

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies

Biochemical evidence for gap junctions and Cx43 expression in immortalized human chondrocyte cell line: a potential model in the study of cell communication in human chondrocytes

mtDNA haplogroups and osteoarthritis in different geographic populations

Tocilizumab in patients with active rheumatoid arthritis and inadequate response to disease-modifying antirheumatic drugs or tumor necrosis factor inhibitors: subanalysis of Spanish results of an open-label study close to clinical practice

Secretome analysis of human mesenchymal stem cells undergoing chondrogenic differentiation

Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Surfing transcriptomic landscapes A step beyond the annotation of chromosome 16 proteome

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis

Osteoarthritis: something is moving

LC-MALDI-TOF/TOF for shotgun proteomics

Multilineage differentiation potential of cells isolated from the human amniotic membrane

Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis

Potential use of the human amniotic membrane as a scaffold in human articular carilage repair

Cell and tissue transplant strategies for joint lesions